PISL: A Large-Scale In Silico Experimental Framework for Agent-Directed Physiological Models

We present in silico, physiologically-based rat liver models that are designed for large-scale and high-performance experimentation and analysis. We refer to the framework used as the parallel in silico liver (PISL). The models include agents. The simulations, intended for exploratory experimentation, are agent-directed. To facilitate reaching our goals the models use multi-scale parallelism, parallel parameter sweeping, parallel partitioning and batch processing, a posteriori analysis, all of which is contained within a high-performance computing infrastructure. The system includes a fully automated simulation and analysis life cycle management component that enables conducting large numbers of in silico experiments under various experimental and model configurations. Here, we present and discuss the main characteristics of these capabilities.